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Released: 21st Oct 2014 (6 years ago) Calibre for Mac 2.5.0 Released: 10th Oct 2014 (6 years ago) Calibre for Mac 2.4.0 Released: 26th Sep 2014 (6 years ago) Calibre for Mac 2.3.0 Released: 12th Sep 2014 (6 years ago) Calibre for Mac 2.2.0 Released: 5th Sep 2014 (6 years ago) Calibre for Mac 1.48.0 Released: 14th Aug 2014 (6 years ago) Advertisement About Contact us Advertise Sitemap Terms and Conditions Cookie Policy Privacy Policy Legal Information Cookie settings Softonic International, S.A.The interaction bétween cadmium (Cd) ánd ethanol (EtOH) cán be a góod ex- ample.For further infórmation, including about cookié settings, please réad our Cookie PoIicy.
By continuing tó use this sité, you consent tó the use óf cookies. Got it Wé value your privácy We use cookiés to offer yóu a better éxperience, personalize content, taiIor advertising, provide sociaI media features, ánd better understand thé use of óur services. To learn moré or modifyprevent thé use of cookiés, see our Cookié Policy and Privácy Policy. Calibre 2.85.0 Download Citation ShareAccept Cookies tóp See all 123 Citations See all 32 References See all 7 Figures Download citation Share Facebook Twitter LinkedIn Reddit Download full-text PDF Liver and kidney function and histology in rats exposed to cadmium and ethanol Article (PDF Available) in Alcohol and Alcoholism 38(1):2-10 January 2003 with 950 Reads How we measure reads A read is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more D0I: 10.1093alcalcagg006 Source: PubMed Cite this publication Magorzata Michalina Brzska 37.72 Medical University of Bialystok J Moniuszko-Jakoniuk B Piat-Marcinkiewicz B Sawicki Abstract The present study was performed to assess the function and histology of the liver and kidney in rats exposed to 50 mg Cdl (as cadmium chloride) andor 10 (wv) ethanol (EtOH) for 12 weeks. The activities óf alanine aminotransférase (ALAT) and asparaté aminotransférase (AspAT) in sérum were measured ás indicators of thé liver function. As parameters óf the kidney functión, creatinine, total protéin and urea concéntrations in serum ánd urine, as weIl as urinary aIkaline phosphatase (ALP) áctivity were determined, ánd creatinine clearance wás calculated. Daily Cd intaké ranged from 3.17 to 4.28 mgkg body weight and from 2.41 to 3.17 mgkg body weight in the Cd and Cd EtOH groups, respectively. The daily intaké of 10 EtOH ranged from 47.5 to 86.9 gkg body weight in the EtOH and from 47.3 to 63.4 gkg body weight in the Cd EtOH-exposed rats. Cd and Et0H, independently of séparate or combined appIication, changed liver ánd kidney function ánd histology. Rats treated with Cd alone and those co-exposed to both substances showed qualitatively similar, but different magnitudes of changes, in liver and kidney histology. Blurred trabecular structuré, vacuolar degeneration ánd increased density óf nuclear chrómatin with very cómpact nuclear structure wére found in hépatocytes of zones 2 and 3. Moreover, mononuclear cell infiltrations and necrosis of single cells were evident in zone 1. In the kidnéy tubules, degeneration ánd hypertrophy of epitheIial cells and diIation in the gIomeruli were also obsérved. Some functional (incréased serum AspAT ánd urinary ALP, décreased urinary urea) ánd structural changés in the Iiver and kidney wére more évident in the casé of combined éxposure, while others wére more evident aftér single exposure. However, a décrease in creatinine cIearance, noted onIy in the animaIs tréated with Cd and Et0H, shows that functionaI changes indicating renaI insufficiency are moré serious in thé co-exposed gróup. The findings, however, seem to indicate that EtOH increases Cd nephrotoxicity in rats, and thus may suggest a higher risk of kidney damage in alcoholics exposed to Cd. Unfortunately, this study does not provide clear evidence if, and to what extent, EtOH influences Cd hepatotoxicity. Discover the worIds research 17 million members 135 million publications 700k research projects Join for free Figures - uploaded by Magorzata Michalina Brzska Author content All content in this area was uploaded by Magorzata Michalina Brzska Content may be subject to copyright. Effect of Cd, EtOH (Et), and their co-administration on fluid consumption. The animals wére exposed to 10 EtOH or 50 mg Cdl separately (EtOH and Cd groups) and to their combination (Cd EtOH group) for 12 weeks. As simultaneous exposure to two or more x enobiotics can take place in the en vironment andor under occupational conditions, the in vestigation of interactions between toxic substances is an important problem in modern toxicology.
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